1-(2-Chloroethyl)-4-phenylpiperazine dihydrochloride → 5-Benzyloxy-2-(2-[4-phenyl-1-piperazinyl]ethylamino)benzamide

Participants

Reaction Steps

1-(2-Chloroethyl)-4-phenylpiperazine dihydrochloride (3.3 g) was converted to the base and added to 1.2 g 5-Benzyloxyanthranilamide in 125 ml propanol. The solution was refluxed 3 hours, cooled, filtered, and the filtrate concentrated to dryness. The residue was chromatographed on alumina to give 0.63 g product.

Provenance & Evidence