Thionyl Chloride → HCID 20338676, compound

HRID 1439616Notes

Reaction equation

HRID 1439616 reaction equation
[ClH:1].O[CH:3]([CH3:17])[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:7][CH2:6]1.S(Cl)([Cl:20])=O>C(Cl)(Cl)Cl>[ClH:20].[ClH:1].[Cl:20][CH:3]([CH3:17])[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:7][CH2:6]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 21395750HCID 21395750, compound

Product 1

HCID 20338676HCID 20338676, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1-(2-Hydroxypropyl)-4-phenylpiperazine hydrochloride (155 g.) was suspended in 1200 ml. dry chloroform and 87.5 ml. thionyl chloride added dropwise. The mixture was refluxed 21/2 hrs, and cooled overnight at room temperature. The solid was filtered, washed with chloroform, them with ether, and dried to give 175 g., m. 216-18° .

Workup

  1. temperatureThe mixture was refluxed 21/2 hrs
  2. filtrationThe solid was filtered
  3. washwashed with chloroform, them with ether
  4. customdried
  5. customto give 175 g
  6. custom216-18°

Sources & evidence

ORD record
ord-863c2927b9114ffabeb6d501c11a1baf
Source dataset
uspto-grants-1977_11
Patent number
US04060526

Reaction notes

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