Pyridine → (5-Oxocyclopent-1-en-1-yl)acetaldehyde

HRID 1439673ノート

反応式

HRID 1439673 の反応式
N1C=CC=CC=1.[OH:7][CH2:8][CH2:9][C:10]1[C:11](=[O:15])[CH2:12][CH2:13][CH:14]=1>[O-2].[O-2].[O-2].[Cr+6].C(Cl)Cl>[CH:8]([CH2:9][C:10]1[C:11](=[O:15])[CH2:12][CH2:13][CH:14]=1)=[O:7]

参加物

5

反応物 2

HCID 1049PyridineHCID 154144942-(2-Hydroxyethyl)cyclopent-2-en-1-one

生成物 1

HCID 20465672(5-Oxocyclopent-1-en-1-yl)acetaldehyde

試薬・触媒・溶媒 2

HCID 10219390chromium (VI) trioxide触媒HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

Chromium trioxide (0.6 mol) is added to a stirring solution of (1.2 mol) of anhydrous pyridine in 1500 ml. of anhydrous methylene chloride cooled in an ice bath. The deep red suspension is stirred for 15 minutes at 0° C. and 45 minutes at ambient temperature. A solution of 01.5 mol of 2-(2-hydroxyethyl)-cyclopent-2-en-1-one (Example 897) in 50 ml. of methylene chloride is added, all at once, to the suspension. A black terry deposit is formed immediately. After stirring the mixture for 25 minutes at ambient temperature, the methylene chloride is decanted from the tarry precipitate which is then triturated several times with ether.

後処理

  1. customA black terry deposit is formed immediately
  2. stirringAfter stirring the mixture for 25 minutes at ambient temperature
  3. customthe methylene chloride is decanted from the tarry precipitate which
  4. customis then triturated several times with ether

出典と根拠

ORDレコード
ord-7658afd9dda34173acee7217b0c1a190
出典データセット
uspto-grants-1977_11
特許番号
US04060540

反応ノート

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