HCID 86735224, compound → HCID 86735223, compound

HRID 1439708Notes

Reaction equation

HRID 1439708 reaction equation
Cl.[CH2:2]([C@@H:4]1[CH2:8][CH2:7][NH:6][C@H:5]1[C:9]([NH2:11])=[O:10])[CH3:3]>O>[OH2:10].[CH2:2]([C@@H:4]1[CH2:8][CH2:7][NH:6][C@H:5]1[C:9]([NH2:11])=[O:10])[CH3:3]

Participants

3

Reactant 1

HCID 86735224HCID 86735224, compound

Product 1

HCID 86735223HCID 86735223, compoundYield 200.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

trans-3-Ethyl-dl-prolineamide hydrochloride (0.5 g) was dissolved in water and passed down a column of DEAE-Sephadex resin (OH- form). The fractions containing product (as detected by t.l.c.) were combined and evaporated to dryness to yield trans-3-ethyl-dl-prolineamide hydrate (0.45 g) as a white solid m.p. 89.5°-91° RF 3A 0.22 RF 3B 0.72

Workup

  1. additionThe fractions containing product (as detected by t.l.c.)
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-a7f881c6d857432090b3dfd003548d54
Source dataset
uspto-grants-1977_11
Patent number
US04060603

Reaction notes

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