HCID 22800291, compound → HCID 178461469, compound

HRID 1439713Notes

Reaction equation

HRID 1439713 reaction equation
C(OC([N:11]1[C:15](=[O:16])[CH2:14][CH2:13][C@H:12]1[C:17]([N:19]([CH3:30])[C@H:20]([C:27]([OH:29])=O)[CH2:21][C:22]1[N:26]=[CH:25][NH:24][CH:23]=1)=[O:18])=O)C1C=CC=CC=1.[CH3:31][C@H:32]1[CH2:36][CH2:35][NH:34][C@@H:33]1[C:37]([NH2:39])=[O:38]>CN(C)C=O>[NH:11]1[C:15](=[O:16])[CH2:14][CH2:13][C@H:12]1[C:17]([N:19]([CH3:30])[C@H:20]([C:27]([N:34]1[CH2:35][CH2:36][C@H:32]([CH3:31])[C@H:33]1[C:37]([NH2:39])=[O:38])=[O:29])[CH2:21][C:22]1[N:26]=[CH:25][NH:24][CH:23]=1)=[O:18]

Participants

4

Reactant 2

HCID 22800291HCID 22800291, compoundHCID 178485746HCID 178485746, compound

Product 1

HCID 178461469HCID 178461469, compoundYield 46.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This was prepared from benzyloxycarbonyl-L-pyroglutamyl-Nα -methyl-L-histidine (207 mg) and trans-3-methyl-L-prolineamide (77 mg) by the method of Example 2(vi) to yield a white hydroscopic solid (90 mg) RF 3A m.p. 135°-140° RF 3B 0.60 (Found C, 55.0; H, 7.0; N, 21.2; C18H23N6O4 requires C, 55.4; H, 6.7; N, 21.5%) [α]D22 - 23.9° (c = 1, dimethylformamide).

Sources & evidence

ORD record
ord-8249993f3bbf49c28224c835914e4e89
Source dataset
uspto-grants-1977_11
Patent number
US04060603

Reaction notes

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