反应详情

A solution of 1,2-epoxy-3-(1-naphthyloxy)propane (62.0 g) and the amine of formula NHR2R3, pyrrolidine (23.5 g), in methanol (250 ml) is heated at reflux for 2 hours. The reaction mixture is concentrated to dryness. The oily residue is crystallized from chloroform and diethyl ether by the addition of hexane to give the title compound, mp 68°-70° C.

1. temperatureat reflux for 2 hours
2. concentrationThe reaction mixture is concentrated to dryness
3. customThe oily residue is crystallized from chloroform and diethyl ether by the addition of hexane