Ammonia → 4-Amino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl)-6,7-dimethoxyquinazoline

HRID 1439720Notes

Reaction equation

HRID 1439720 reaction equation
[NH3:1].Cl[C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=2)[N:6]=[C:5]([N:17]2[CH2:22][CH2:21][N:20]([C:23]([CH:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[O:24])[CH2:19][CH2:18]2)[N:4]=1>O1CCCC1>[NH2:1][C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=2)[N:6]=[C:5]([N:17]2[CH2:22][CH2:21][N:20]([C:23]([CH:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[O:24])[CH2:19][CH2:18]2)[N:4]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 211839834-Chloro-2-[4-(cyclopentylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline

Product 1

HCID 211838874-Amino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl)-6,7-dimethoxyquinazoline

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of anhydrous ammonia and 4-chloro-2-[4-(cyclopentylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline in 100 ml. of tetrahydrofuran is heated at 100° C. for a period of 16 to 24 hours and the product isolated according to the procedure of Example 1(a) to provide 4-amino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline.

Workup

  1. customthe product isolated

Sources & evidence

ORD record
ord-5c5415b4db42479a8b20982889b695fd
Source dataset
uspto-grants-1977_11
Patent number
US04060615

Reaction notes

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