1-Cyclopentanecarbonylpiperazine → 4-Amino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl)-6,7-dimethoxyquinazoline

HRID 1439721Notes

Reaction equation

HRID 1439721 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4](SC)[N:3]=1.[CH:18]1([C:23]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[O:24])[CH2:22][CH2:21][CH2:20][CH2:19]1>C(O)CC(C)C>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4]([N:28]2[CH2:29][CH2:30][N:25]([C:23]([CH:18]3[CH2:19][CH2:20][CH2:21][CH2:22]3)=[O:24])[CH2:26][CH2:27]2)[N:3]=1

Participants

4

Reactant 2

HCID 155127791-CyclopentanecarbonylpiperazineHCID 538625236,7-Dimethoxy-2-(methylthio)quinazolin-4-amine

Product 1

HCID 211838874-Amino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl)-6,7-dimethoxyquinazoline

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

A mixture of 4-amino-2-methylmercapto-6,7-dimethoxyquinazoline (0.1 mole) and from 0.1 to 0.15 mole of N-(cyclopentylcarbonyl)piperazine in 150 ml. of isoamyl alcohol is refluxed for a period of 8 to 24 hours. The solvent is evaporated and residual material, treated according to procedure of Example 1(a), provides 4-amino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline.

Workup

  1. customThe solvent is evaporated
  2. additionresidual material, treated

Sources & evidence

ORD record
ord-a24bca1359b449fc819a9e8668dc3944
Source dataset
uspto-grants-1977_11
Patent number
US04060615

Reaction notes

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