1-Cyclopentanecarbonylpiperazine → 4-Amino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl)-6,7-dimethoxyquinazoline

Participants

Role	Name	HCID	Charge
Reactant	1-Cyclopentanecarbonylpiperazine	HCID 15512779	—
Reactant	6,7-Dimethoxy-2-(methylthio)quinazolin-4-amine	HCID 53862523	—
Solvent	Isoamyl Alcohol	HCID 31260	—
Product	4-Amino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl)-6,7-dimethoxyquinazoline	HCID 21183887	—

Reaction Steps

A mixture of 4-amino-2-methylmercapto-6,7-dimethoxyquinazoline (0.1 mole) and from 0.1 to 0.15 mole of N-(cyclopentylcarbonyl)piperazine in 150 ml. of isoamyl alcohol is refluxed for a period of 8 to 24 hours. The solvent is evaporated and residual material, treated according to procedure of Example 1(a), provides 4-amino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04060615
Source dataset	uspto-grants-1977_11
ORD ID	ord-a24bca1359b449fc819a9e8668dc3944
Source note	uspto-grants-1977_11