Sodium hydride → 6,7-Dimethoxyquinazoline

HRID 1439722Notes

Reaction equation

HRID 1439722 reaction equation
Cl.[CH2:2](NC(N1CCN(C(C2CCCC2)=O)CC1)=O)C.[CH3:20][O:21][C:22]1[C:29]([O:30][CH3:31])=[CH:28][C:25]([C:26]#[N:27])=[C:24]([NH2:32])[CH:23]=1.[H-].[Na+]>O>[CH3:31][O:30][C:29]1[CH:28]=[C:25]2[C:24](=[CH:23][C:22]=1[O:21][CH3:20])[N:32]=[CH:2][N:27]=[CH:26]2

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 7359672-Amino-4,5-dimethoxybenzonitrileHCID 68124700HCID 68124700, compound

Product 1

HCID 30316616,7-Dimethoxyquinazoline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethyl-4-(cyclopentylcarbonyl)piperazin-1-yl-formamidate hydrochloride (0.01 mole) is added to a solution of 4,5-dimethoxy-2-aminobenzonitrile (0.01 mole) in 30 ml. of N1N-dimethylformamide. Sodium hydride (0.02 mole of a 56% suspension in mineral oil) is added and the mixture stirred 0.5 hr. at room temperature and then at 100° C. for a period of 12 hr. When the reaction period is complete, water is added providing 4-amino-2-[4-cyclopentylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline.

Workup

  1. waitat room temperature and then at 100° C. for a period of 12 hr
  2. customWhen the reaction period

Sources & evidence

ORD record
ord-2ddd160ee9dc4e8e8fb37fcee741b172
Source dataset
uspto-grants-1977_11
Patent number
US04060615

Reaction notes

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