huagongshe.com
HRID1439723

反应详情

EQUATION

反应方程式

HRID 1439723 的结构方程式

REACTANTS

反应物

2
结构：COc1cc2nc(Cl)nc(N)c2cc1OC
HCID90235

4-Amino-2-chloro-6,7-dimethoxyquinazoline

C10H10ClN3O2

结构：O=C(C1CC1)N1CCNCC1
HCID2064235

Cyclopropyl(1-piperazinyl)methanone

C8H14N2O

PRODUCTS

生成物

1
结构：COc1cc2nc(N3CCN(C(=O)C4CC4)CC3)nc(N)c2cc1OC
HCID20473772

未命名化合物

PROCEDURE

实验过程

N-(Cyclopropylcarbonyl)piperazine (3.08 g., 0.02 mole) and 2-chloro-4-amino-6,7-dimethoxyquinazoline (4.74 g., 0.02 mole) are reacted according to the procedure of Example 1(a). The crude product crystallized from ethanol affords analytically pure 4-amino-2-[4-(cyclopropylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline, m.p. 283.5°-285.5° C. (corr.).

WORKUP

后处理

  1. customThe crude product crystallized from ethanol