HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6,7-dimethoxy-4-quinazolinamine → 4-Amino-2-[4-(cyclopropylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6,7-dimethoxy-4-quinazolinamine | HCID 90235 | — |
| Reactant | 1-(Cyclopropylcarbonyl)piperazine | HCID 2064235 | — |
| Product | 4-Amino-2-[4-(cyclopropylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline | HCID 20473772 | — |
Reaction Steps
N-(Cyclopropylcarbonyl)piperazine (3.08 g., 0.02 mole) and 2-chloro-4-amino-6,7-dimethoxyquinazoline (4.74 g., 0.02 mole) are reacted according to the procedure of Example 1(a). The crude product crystallized from ethanol affords analytically pure 4-amino-2-[4-(cyclopropylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline, m.p. 283.5°-285.5° C. (corr.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04060615 |
| Source dataset | uspto-grants-1977_11 |
| ORD ID | ord-1e0d1c193cfa4412bad32091c4ba7984 |
| Source note | uspto-grants-1977_11 |