2-Chloro-4-hydrazino-6,7-dimethoxyquinazoline → 4-Hydrazino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazolinehydrochloride

HRID 1439730Notes

Reaction equation

[CH:1]1([C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:14][C:15]1[N:24]=[C:23]([NH:25][NH2:26])[C:22]2[C:17](=[CH:18][C:19]([O:29][CH3:30])=[C:20]([O:27][CH3:28])[CH:21]=2)[N:16]=1>>[ClH:14].[NH:25]([C:23]1[C:22]2[C:17](=[CH:18][C:19]([O:29][CH3:30])=[C:20]([O:27][CH3:28])[CH:21]=2)[N:16]=[C:15]([N:11]2[CH2:10][CH2:9][N:8]([C:6]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5]3)=[O:7])[CH2:13][CH2:12]2)[N:24]=1)[NH2:26]

Participants

Reactant 2

HCID 640302-Chloro-4-hydrazino-6,7-dimethoxyquinazoline

HCID 155127791-Cyclopentanecarbonylpiperazine

Product 1

HCID 211839294-Hydrazino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazolinehydrochloride

Procedure

N-(Cyclopentylcarbonyl)piperazine (0.02 mole) and 2-chloro-4-hydrazino-6,7-dimethoxyquinazoline (0.02 mole) reacted according to the procedure of Example 7 provides 4-hydrazino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazolinehydrochloride, m.p. 282°-284° C.

Sources & evidence

ORD record: ord-d5f7655241924a1b8cba8a1069df4a98
Source dataset: uspto-grants-1977_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04060615

Reaction notes

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