4-(Pyridin-2-yl)butan-1-amine → HCID 178512150, compound

HRID 1439744Notes

Reaction equation

HRID 1439744 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1.CS[C:14](=[NH:19])[NH:15][N+:16]([O-:18])=[O:17]>CO>[N:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[CH2:5][CH2:4][CH2:3][CH2:2][NH:1][C:14]([NH:15][N+:16]([O-:18])=[O:17])=[NH:19]

Participants

4

Reactant 2

HCID 135110834-(Pyridin-2-yl)butan-1-amineHCID 135927615N-Nitro-S-methylisothiourea

Product 1

HCID 178512150HCID 178512150, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-(4-aminobutyl)pyridine (2.9 g) and S-methyl-N-nitroisothiourea (2.9 g) in methanol (50 ml) was heated at 50-65° for 4-5 hours. Concentration, followed by recrystallisation of the residue yielded N-[4-(2-pyridyl)butyl]-N'-nitroguanidine.

Workup

  1. concentrationConcentration
  2. customfollowed by recrystallisation of the residue

Sources & evidence

ORD record
ord-a8c2b2ddd9164ec193eb1ff0e98dd278
Source dataset
uspto-grants-1977_11
Patent number
US04060621

Reaction notes

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