反应详情

A solution of 3-methyl-2-((2-aminoethyl)thiomethyl)pyridine (6.3 g) and N-benzenesulphonyl-S-methylisothiourea (8.0 g) in acetonitrile (100 ml) was heated under reflux for 24 hours. Concentration, followed by chromatographic purification on a column of silica gel and recrystallisation afforded N-benzenesulphonyl-N"-[2-((3-methyl-2-pyridyl)methylthio)ethyl]guanidine.

1. temperatureunder reflux for 24 hours
2. concentrationConcentration
3. customfollowed by chromatographic purification on a column of silica gel and recrystallisation