反应详情

4,5,6,7-Tetrahydro-7-oxobenzo[b]thien-4-ylurea (5 g., 0.0238 mole) and hydroxylamine hydrochloride (2 g., 0.028 mole) in dry pyridine (50 ml.) are stirred together at room temperature under nitrogen overnight. The resulting clear solution is evaporated and the residual gum triturated with water (50 ml.) and the brown solid obtained is collected, washed with water and air dried (5.15 g.). The solid is recrystallized from hot methanol to afford 2.95 g. of the title compound m.p. 232°-233° C. dec.

1. customThe resulting clear solution is evaporated
2. customthe residual gum triturated with water (50 ml.)
3. customthe brown solid obtained
4. customis collected
5. washwashed with water and air
6. customdried (5.15 g.)
7. customThe solid is recrystallized from hot methanol
8. customto afford 2.95 g