Chlorine → HCID 21396480, compound

HRID 1439767Notes

Reaction equation

HRID 1439767 reaction equation
[C:1]([CH2:3][CH2:4][C:5]([C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:10][CH:9]=1)([OH:7])[CH3:6])#[N:2].[Cl:21]Cl>C(O)(=O)C>[C:1]([CH2:3][CH2:4][C:5]([C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)=[CH:10][CH:9]=1)([OH:7])[CH3:6])#[N:2]

Participants

4

Reactant 2

HCID 24526ChlorineHCID 21396526HCID 21396526, compound

Product 1

HCID 21396480HCID 21396480, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

2.76 g. of 1-cyano-3-(4-phenoxy-phenyl)-butan-3-ol are dissolved in 20 ml. of acetic acid, a solution of 0.8 g. of chlorine in 20 ml. of acetic acid is added dropwise at 20° while stirring, the mixture is stirred for a further one hour and evaporated and the residue is worked up in the customary manner to give 1-cyano-3-(4-p-chlorophenoxy-phenyl)-butan-3-ol, m.p. 68° - 70°.

Workup

  1. stirringthe mixture is stirred for a further one hour
  2. customevaporated

Sources & evidence

ORD record
ord-51a21250182e4a559e392948a4645a18
Source dataset
uspto-grants-1977_11
Patent number
US04060633

Reaction notes

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