1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 1069-29-0

HRID 1439950Notes

Reaction equation

HRID 1439950 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:17])[C@@H:5]([NH2:16])[CH2:6][S:7][S:8][CH2:9][C@H:10]([NH2:15])[C:11]([O:13][CH3:14])=[O:12].CN(CCCN=C=NCC)C>O>[CH3:2][O:3][C:4](=[O:17])[C@@H:5]([NH2:16])[CH2:6][S:7][S:8][CH2:9][C@H:10]([NH2:15])[C:11]([O:13][CH3:14])=[O:12]

Participants

4

Reactant 2

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 8674930632854-09-4

Product 1

HCID 27243771069-29-0

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

5 g of polymer (2) and 5.3 g of cystine dimethyl ester hydrochloride are dissolved in 100 ml of water. 6 g of N-dimethylaminopropyl-N'-ethylcarbodiimide (EDC) are then dissolved in 5 ml of water and immediately added to the reaction mixture. The mixture immediately turns dark red and, after a few seconds, a pink precipitate is then formed. The reaction is stopped after 3 hours and 200 ml of water are added. The precipitate is recovered by filtration, washed several times with water and then oven-dried under vacuum.

Workup

  1. additionimmediately added to the reaction mixture
  2. waitThe mixture immediately turns dark red and, after a few seconds
  3. customa pink precipitate is then formed
  4. filtrationThe precipitate is recovered by filtration
  5. washwashed several times with water
  6. customoven-dried under vacuum

Sources & evidence

ORD record
ord-55e5411d4b7f4bf9a3d3c2d78a4834bb
Source dataset
uspto-grants-1996_03
Patent number
US05496872

Reaction notes

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