1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 583-89-1

HRID 1439951Notes

Reaction equation

HRID 1439951 reaction equation
Cl.[CH2:2]([O:4][C:5](=[O:19])[C@@H:6]([NH2:18])[CH2:7][S:8][S:9][CH2:10][C@H:11]([NH2:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH3:3].CN(CCCN=C=NCC)C>O>[CH2:2]([O:4][C:5](=[O:19])[C@@H:6]([NH2:18])[CH2:7][S:8][S:9][CH2:10][C@H:11]([NH2:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH3:3]

Participants

4

Reactant 2

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 8674930722735-07-5

Product 1

HCID 6993069583-89-1

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

5 g of polymer (2) and 5.73 g of cystine diethyl ester hydrochloride are dissolved in 100 ml of water. 6 g of N-dimethylaminopropyl-N'-ethylcarbodiimide (EDC) are then dissolved in 5 ml of water and immediately added to the reaction mixture. The reaction is stopped after 3 hours and 200 ml of water are added. The precipitate is recovered by filtration, washed several times with water and then oven-dried under vacuum.

Workup

  1. additionimmediately added to the reaction mixture
  2. filtrationThe precipitate is recovered by filtration
  3. washwashed several times with water
  4. customoven-dried under vacuum

Sources & evidence

ORD record
ord-7ce91a8c69d24dffb3851b3d3471c263
Source dataset
uspto-grants-1996_03
Patent number
US05496872

Reaction notes

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