反应详情

A process for the synthesis of 9-(2-hydroxyethoxy methyl) guanine, comprising reacting guanine, or a salt thereof with between 2 and 4 moles of hexamethyldisilazane, in the presence of an aprotic solvent and of a catalytic amount of ammonium sulphate; reacting the resulting guanine trimethylsilyl derivative, without being isolated, with a stoichiometric quantity of acyloxyethoxy methyl halide at a temperature of 50° to 100° C.; and hydrolyzing with a sodium acetate or sodium hydroxyde water solution the resulting 9-(2-acetoxyethoxy methyl) guanine, to provide 9-(2-hydroxyethoxy methyl) guanine.