Hydrochloric Acid → HCID 10710803, compound

HRID 1440019Notes

Reaction equation

HRID 1440019 reaction equation
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:19])=[C:15]([F:18])[CH:16]=2)[C:11](=[O:20])[C:10]([C:21]([O:23]CC)=[O:22])=[CH:9]1.O.Cl>C(O)C>[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:19])=[C:15]([F:18])[CH:16]=2)[C:11](=[O:20])[C:10]([C:21]([OH:23])=[O:22])=[CH:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 10617686HCID 10617686, compound

Product 1

HCID 10710803HCID 10710803, compoundYield 91.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5 g of ethyl 1-(3-fluoro-4-pyridyl)-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate is added with 20 ml of water, 30 ml of ethanol and 15 ml of conc. hydrochloric acid and refluxed for 8 hours. After cooling to room temperature and standing for 2 hours, filtering and drying are carried out to obtain 4.2 g of the desired compound.

Workup

  1. temperaturerefluxed for 8 hours
  2. filtrationfiltering
  3. customdrying

Sources & evidence

ORD record
ord-c14f587347ce4eca8b3ecb4f63868351
Source dataset
uspto-grants-1996_03
Patent number
US05496947

Reaction notes

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