Hydrochloric Acid → HCID 70285138, compound

HRID 1440022Notes

Reaction equation

HRID 1440022 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:24])=[C:15]([N:18]4[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]4)[N:16]=3)[C:11](=[O:25])[C:10]([C:26]([O:28]CC)=[O:27])=[CH:9]2)=[N:6][CH:7]=1.[ClH:31]>O>[ClH:31].[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:24])=[C:15]([N:18]4[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]4)[N:16]=3)[C:11](=[O:25])[C:10]([C:26]([OH:28])=[O:27])=[CH:9]2)=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10669529HCID 10669529, compound

Product 1

HCID 70285138HCID 70285138, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.5 g of ethyl 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(1-piperazinyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate is added to 10 ml of water and 10 ml of conc. hydrochloric acid. The mixture is refluxed for 24 hours, cooled to room temperature and concentrated under a reduced pressure. The concentrate is added with 20 ml of ethanol and stirred at room temperature for 2 hours, filtered and dried. The product is recrystallized in a mixed solvent of water and methanol to obtain 0.39 g of the desired compound.

Workup

  1. temperatureThe mixture is refluxed for 24 hours
  2. concentrationconcentrated under a reduced pressure
  3. additionThe concentrate is added with 20 ml of ethanol
  4. filtrationfiltered
  5. customdried
  6. customThe product is recrystallized in a mixed solvent of water and methanol

Sources & evidence

ORD record
ord-11390fd3e18744fc83b6a1c2c708dc90
Source dataset
uspto-grants-1996_03
Patent number
US05496947

Reaction notes

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