Hydrochloric Acid → HCID 18985350, compound

HRID 1440092Notes

Reaction equation

HRID 1440092 reaction equation
[OH-].[Na+].[F:3][C:4]1[C:14]([O:15][C:16]([F:19])([F:18])[F:17])=[C:13]([F:20])[C:12]([F:21])=[CH:11][C:5]=1[C:6]([O:8]CC)=[O:7].Cl>C(O)C>[F:3][C:4]1[C:14]([O:15][C:16]([F:17])([F:18])[F:19])=[C:13]([F:20])[C:12]([F:21])=[CH:11][C:5]=1[C:6]([OH:8])=[O:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18985348HCID 18985348, compound

Product 1

HCID 18985350HCID 18985350, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

19.3 ml (0.0193 moles) of a 1N aqueous solution of sodium hydroxide were added t9 a solution of 5.05 g (0.0175 moles) of ethyl 2,4,5-trifluoro-3-trifluoromethoxybenzoate [(XXVIII), X=X'=F, R16 =C2H5O] [prepared as described in step (b) above] in 100 ml of ethanol, and the mixture was allowed to stand at room temperature for 2 hours. At the end of this time, 19.3 ml of 1N aqueous hydrochloric acid were added, and then the reaction mixture was concentrated by evaporation under reduced pressure. The residue was then extracted with ethyl acetate. The extract was washed with water, dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure, to give 3.98 g of 2,4,5-trifluoro-3-trifluoromethoxybenzoic acid as a colorless powder.

Workup

  1. concentrationthe reaction mixture was concentrated by evaporation under reduced pressure
  2. extractionThe residue was then extracted with ethyl acetate
  3. washThe extract was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-b7c7544f31544eefa2a4537d3c0f4232
Source dataset
uspto-grants-1996_03
Patent number
US05496951

Reaction notes

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