3,4,6-Trifluoro-5-hydroxyphthalic acid → 2,4,5-Trifluoro-3-hydroxybenzoic Acid

HRID 1440107Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1440107
[F:1][C:2]1[C:10]([OH:11])=[C:9]([F:12])[C:8]([F:13])=[C:4](C(O)=O)[C:3]=1[C:14]([OH:16])=[O:15]>O>[F:1][C:2]1[C:10]([OH:11])=[C:9]([F:12])[C:8]([F:13])=[CH:4][C:3]=1[C:14]([OH:16])=[O:15]

Komponenten

3

Edukt 1

HCID 101985873,4,6-Trifluoro-5-hydroxyphthalic acid

Produkt 1

HCID 27342702,4,5-Trifluoro-3-hydroxybenzoic AcidAusbeute 73,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

2700 g of 3,5,6-trifluoro-4-hydroxyphthalic acid and 6 liters of water were placed in an autoclave, and the mixture was heated at 140° C for 3 hours in an atmosphere of nitrogen. At the end of this time, the reaction mixture was cooled to room temperature and concentrated by evaporation under reduced pressure, to precipitate crystals, which were collected by filtration, washed with chloroform and dried to give 1623 g of 2,4,5-trifluoro-3-hydroxybenzoic acid [(XXIII), X =X'=F] as a colorless powder, melting at 144°-146° C.

Aufarbeitung

  1. temperatureAt the end of this time, the reaction mixture was cooled to room temperature
  2. concentrationconcentrated by evaporation under reduced pressure
  3. customto precipitate crystals, which
  4. filtrationwere collected by filtration
  5. washwashed with chloroform
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4904213de4484068888be6bdd0667cd6
Quelldatensatz
uspto-grants-1996_03
Patentnummer
US05496951

Notizen zur Reaktion

Wird geladen…