N-(3-Aminopropyl)morpholine → HCID 18982841, compound

HRID 1440199Notes

Reaction equation

C(O[C:4]([C:6]1[C:22]2[C:10](=[C:11]([CH3:25])[C:12]3[N:13]([CH3:24])[C:14]4[CH:15]=[CH:16][C:17]([OH:23])=[CH:18][C:19]=4[C:20]=3[CH:21]=2)[CH:9]=[CH:8][N:7]=1)=[O:5])C.[NH2:26][CH2:27][CH2:28][CH2:29][N:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[O:33]1[CH2:34][CH2:35][N:30]([CH2:29][CH2:28][CH2:27][NH:26][C:4]([C:6]2[C:22]3[C:10](=[C:11]([CH3:25])[C:12]4[N:13]([CH3:24])[C:14]5[CH:15]=[CH:16][C:17]([OH:23])=[CH:18][C:19]=5[C:20]=4[CH:21]=3)[CH:9]=[CH:8][N:7]=2)=[O:5])[CH2:31][CH2:32]1

Participants

Reactant 2

HCID 61055N-(3-Aminopropyl)morpholine

HCID 10246273HCID 10246273, compound

Product 1

HCID 18982841HCID 18982841, compound

Conditions

Temperature: 120 °C

Procedure

0.36 g (1.078 mmol) of the ester obtained in Step A of Example 11 are dissolved in 10 ml of 4-(3-aminopropyl)morpholine under an argon atmosphere. The mixture is heated at 120° C. for 19 hours.

Sources & evidence

ORD record: ord-44efdbb0c50740fd91f355c872b21057
Source dataset: uspto-grants-1996_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05498611

Reaction notes

Loading…