Trifluoroacetic acid → HCID 67770941, compound

HRID 1440233Notes

Reaction equation

HRID 1440233 reaction equation
FC(F)(F)C(O)=O.C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:15]2[C:19](=[O:20])[CH:18]([C:21]3[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][CH:22]=3)[O:17][C:16]2=[O:28])C=CC=CC=1>O>[OH:27][C:24]1[CH:23]=[CH:22][C:21]([CH:18]2[O:17][C:16](=[O:28])[NH:15][C:19]2=[O:20])=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67771903HCID 67771903, compound

Product 1

HCID 67770941HCID 67770941, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 10 ml of trifluoroacetic acid was added 500 mg of 3-triphenylmethyl-5-p-hydroxyphenyl-2,4-oxazolidinedione and the reaction mixture stirred at room temperature for 10 minutes. The reaction was poured into 50 ml of water and extracted with ethyl acetate. The organic layer was separated, washed with water (2×40 ml) and dried over sodium sulfate. Removal of the solvent in vacuo gave a yellow solid which was recrystallized from ethyl acetate-cyclohexane, 226 mg.

Workup

  1. extractionextracted with ethyl acetate
  2. customThe organic layer was separated
  3. washwashed with water (2×40 ml)
  4. dry with materialdried over sodium sulfate
  5. customRemoval of the solvent in vacuo
  6. customgave a yellow solid which
  7. customwas recrystallized from ethyl acetate-cyclohexane, 226 mg

Sources & evidence

ORD record
ord-39fc9a175cc14794ad6d714ffae94434
Source dataset
uspto-grants-1996_03
Patent number
US05498621

Reaction notes

Loading…