反应详情

A mixture of NaOEt (0.069 mol) in EtOH (prepared from 1.6 g of Na and 35 mL of EtOH), acetamidine hydrochloride (3.3 g, 0.035 mol), and diethyl acetylglutarate (8.0 g, 0.035 mol) was heated under reflux for 22 h. The mixture was concentrated, taken up in water, acidified to pH 4 with conc. HCl, and extracted with EtOAc. The extracts were washed with brine, dried (MgSO4), and concentrated. Trituration with hexane gave 4.0 g (51%) of product as a white solid. An analytical sample was crystallized from ether/hexane, mp 114°-116° C.

1. temperaturewas heated
2. temperatureunder reflux for 22 h
3. concentrationThe mixture was concentrated
4. extractionextracted with EtOAc
5. washThe extracts were washed with brine
6. dry with materialdried (MgSO4)
7. concentrationconcentrated