反应详情

A mixture of ethyl 3-(2,6-dimethyl-3H-pyrimidin-4-on-5yl)propionate (3.87 g, 0.017 mol), phosphorus oxychloride (40 mL), and N,N-dimethylaniline (10 drops) was heated under reflux for 2 h. The mixture was concentrated, cooled, and ice water was added. Solid KOH was added to bring the pH to 6 and the mixture was extracted with ether. The extracts were dried (MgSO4) and concentrated to give 2.95 g (72%) of product as a brown oil.

1. temperaturewas heated
2. temperatureunder reflux for 2 h
3. concentrationThe mixture was concentrated
4. temperaturecooled
5. additionice water was added
6. additionSolid KOH was added
7. extractionthe mixture was extracted with ether
8. dry with materialThe extracts were dried (MgSO4)
9. concentrationconcentrated