反应详情

温度

-78 °C

To a cooled (-78° C.), stirred solution of 2-bromo-5-(tert-butyldimethylsilyloxy)methylpyridine (6.8 g, 0.022 mol) in THF (60 mL) was added 1.6M nBuLi in hexanes (14.1 mL, 0.22 mol). After 1 h, tri-n-butyltin chloride (6.1 mL, 0.022 mol) was added and stirring was continued for 3 h. Water was added, and the mixture was warmed to room temperature and extracted with ether. The combined extracts were dried (MgSO4) and concentrated to give 11.5 g (100%) of product as a brown oil.

1. waitwas continued for 3 h
2. temperaturethe mixture was warmed to room temperature
3. extractionextracted with ether
4. dry with materialThe combined extracts were dried (MgSO4)
5. concentrationconcentrated