Trifluoroacetic acid → Trifluoroacetic acid

HRID 14407Notes

Reaction equation

HRID 14407 reaction equation
C(OC([NH:8][C:9]1[NH:35][CH2:34][C:33]2[CH:36]=[C:37]([Cl:38])[C:30](=[C:31]([Cl:39])[CH:32]=2)[NH:29][C:28](=[O:40])[CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25][CH:24]=[CH:23][CH2:22][O:21][C:20]2[CH:48]=[CH:49][C:17](=[CH:18][CH:19]=2)[C:16]2[C:12](=[C:13]([CH3:50])[O:14][N:15]=2)[C:11](=[O:51])[N:10]=1)=O)(C)(C)C.[C:52]([OH:58])([C:54]([F:57])([F:56])[F:55])=[O:53]>C(Cl)Cl>[NH2:8][C:9]1[NH:35][CH2:34][C:33]2[CH:32]=[C:31]([Cl:39])[C:30](=[C:37]([Cl:38])[CH:36]=2)[NH:29][C:28](=[O:40])[CH2:27][NH:26][CH2:25][CH:24]=[CH:23][CH2:22][O:21][C:20]2[CH:19]=[CH:18][C:17](=[CH:49][CH:48]=2)[C:16]2[C:12](=[C:13]([CH3:50])[O:14][N:15]=2)[C:11](=[O:51])[N:10]=1.[C:52]([OH:58])([C:54]([F:57])([F:56])[F:55])=[O:53]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178434971HCID 178434971, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 178434972HCID 178434972, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The intermediate (24 mg) from Step 1(C) was dissolved in 2 mL of TFA and DCM mixture (1:1). The resulted solution was stirred at room temperature for 1 h. TFA and DCM were evaporated in vacuo to give a crude product, which was purified by preparative HPLC to give the title compound as a TFA salt (19.9 mg).

Workup

  1. customTFA and DCM were evaporated in vacuo
  2. customto give a crude product, which
  3. customwas purified by preparative HPLC

Sources & evidence

ORD record
ord-3ea9f59c3a734f2d85e5952b94dbcea4
Source dataset
uspto-grants-2010_06
Patent number
US07732434B2

Reaction notes

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