Hydrochloric Acid → HCID 15818756, compound

Participants

Reaction Steps

A mixture of 3.0 g of compound C and 1.43 g of powdered KOH in 20 cc ethanol was heated under reflux for 2 hours. After cooling, the reaction mixture was acidified with 1N HCl, and extracted with chloroform. The extract was dried over magnesium sulfate, and distilled to remove the solvent. Thus, 2.75 g of 4-(2-chlorophenyl)-2-phenyl-6-methyl-5-pyrimidinecarboxylic acid was obtained. Yield: 99.6%.

Provenance & Evidence