Hydrochloric Acid → HCID 15818756, compound

HRID 1440785Notes

Reaction equation

HRID 1440785 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:13]([C:14]([O:16]CC)=[O:15])=[C:12]([CH3:19])[N:11]=[C:10]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:9]=1.[OH-].[K+].Cl>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:13]([C:14]([OH:16])=[O:15])=[C:12]([CH3:19])[N:11]=[C:10]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[N:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 18981991HCID 18981991, compound

Product 1

HCID 15818756HCID 15818756, compoundYield 99.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3.0 g of compound C and 1.43 g of powdered KOH in 20 cc ethanol was heated under reflux for 2 hours. After cooling, the reaction mixture was acidified with 1N HCl, and extracted with chloroform. The extract was dried over magnesium sulfate, and distilled to remove the solvent. Thus, 2.75 g of 4-(2-chlorophenyl)-2-phenyl-6-methyl-5-pyrimidinecarboxylic acid was obtained. Yield: 99.6%.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. temperatureAfter cooling
  4. extractionextracted with chloroform
  5. dry with materialThe extract was dried over magnesium sulfate
  6. distillationdistilled
  7. customto remove the solvent

Sources & evidence

ORD record
ord-1b9f2d03e32d435f9f950d8ee45bdd61
Source dataset
uspto-grants-1996_03
Patent number
US05500424

Reaction notes

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