反应详情

A mixture of 5.70 g of compound E and 2.83 g of potassium hydroxide in 40 cc of ethanol and 0.5 cc of water was heated under reflux for 3 hours. After cooling, the reaction mixture was acidified with 1N HCl, and extracted with chloroform. The extract was dried over magnesium sulfate, and distilled to remove the solvent. Thus, 5.20 g of 4-(2-chlorophenyl)-2-phenyl-5-pyrimidinecarboxylic acid was obtained. Yield: 99.6%.

1. temperaturewas heated
2. temperatureunder reflux for 3 hours
3. temperatureAfter cooling
4. extractionextracted with chloroform
5. dry with materialThe extract was dried over magnesium sulfate
6. distillationdistilled
7. customto remove the solvent