HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetamidine monohydrochloride → Ethyl 4-(2-chlorophenyl)-2-methylpyrimidine-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetamidine monohydrochloride | HCID 67170 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | Ethyl 4-(2-chlorophenyl)-2-phenyl-5-pyrimidinecarboxylate | HCID 18981984 | — |
| Reactant | Ethyl 2-(2-chlorobenzoyl)-3-dimethylaminopropenoate | HCID 54509863 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 4-(2-chlorophenyl)-2-methylpyrimidine-5-carboxylate | HCID 18981952 | 73.7% |
Reaction Steps
To a stirred solution of 2.09 g of acetoamidine hydrochloride in 50 cc of ethanol was added 1.50 g of sodium ethoxide at room temperature and the mixture was stirred for 10 minutes. The resulting suspension was added to 6.1 g of compound D in 50 cc of ethanol and the resulting mixture was heated under reflux for 6 hours. Thereafter, 4.5 g of compound F was obtained in the same manner as for compound E. Yield: 73.7%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05500424 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-f987d3c04a524e188ceb97eebee17dc9 |
| Source note | uspto-grants-1996_03 |