Ammonium Acetate → 2-(2-Chlorophenyl)-6-n-heptyl-3-pyridinecarboxylic acid

HRID 1440793ノート

反応式

HRID 1440793 の反応式
O=[C:2]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:3][CH2:4][CH:5]([C:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:18])[C:6]([O:8]CC)=[O:7].C([O-])(=O)C.[NH4+].C1(C2C(C(OCC)=O)=CC=C(C3C=CC=CC=3)[N:39]=2)C=CC=CC=1.C(C(CCC(=O)C1C=CC=CC=1)C(OCC)=O)(=O)C1C=CC=CC=1>C(O)(=O)C>[Cl:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:11]1[C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=[C:2]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[N:39]=1

参加物

6

反応物 4

HCID 517165Ammonium AcetateHCID 12015084Ethyl 2-benzoyl-5-oxo-5-phenylvalerateHCID 189819482, 6-Diphenyl-3-pyridinecarboxylic acid ethyl esterHCID 18981976Ethyl 5-oxo-2-(2-chlorobenzoyl)laurate

生成物 1

HCID 189820192-(2-Chlorophenyl)-6-n-heptyl-3-pyridinecarboxylic acid収率 70.6%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 0.90 g of compound I, 2.73 g of ammonium acetate and 2.80 g of ferric chloride hexahydrate in 20 cc of acetic acid was heated under reflux for 8 hours. Thereafter, 0.60 g of compound J was obtained in the same manner as in the production of compound H from compound G, Yield: 70.6%.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 8 hours

出典と根拠

ORDレコード
ord-9b36d2650b6d4e548fba15a30ba98542
出典データセット
uspto-grants-1996_03
特許番号
US05500424

反応ノート

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