Tetrabutylammonium Fluoride → HCID 22859577, compound

HRID 1441066Notes

Reaction equation

HRID 1441066 reaction equation
[C:1]([C:4]1[S:8][C:7]([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[N:14]([Si](C(C)C)(C(C)C)C(C)C)[CH:13]=[C:12]3[CH2:28][C@H:29]2[CH2:33][CH2:32][CH2:31][N:30]2[CH3:34])=[CH:6][CH:5]=1)(=[O:3])[NH2:2].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[C:1]([C:4]1[S:8][C:7]([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][CH:13]=[C:12]3[CH2:28][C@H:29]2[CH2:33][CH2:32][CH2:31][N:30]2[CH3:34])=[CH:6][CH:5]=1)(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 22859578HCID 22859578, compound

Product 1

HCID 22859577HCID 22859577, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-(5-Carbamoyl-2-thienyl)-3-(1-methylpyrrolidin-2(R)-ylmethyl)-1-triisopropylsilylindole (see Preparation 61) was reacted with tetra-n-butylammonium fluoride in tetrahydrofuran, using a procedure similar to that described in Example 62. This yielded the title compound as an off-white foam. Found: C,64.93; H,6.33; N,11.60. C19H21N3OS.3/16CH2Cl2 requires: C,64.84; H,6.06; N,11.82%.

Sources & evidence

ORD record
ord-6d62560d63574530823bafece0939057
Source dataset
uspto-grants-1996_03
Patent number
US05502065

Reaction notes

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