Tetrabutylammonium Fluoride → HCID 22859581, compound

HRID 1441067Notes

Reaction equation

HRID 1441067 reaction equation
[CH3:1][O:2][C:3]([C:5]1[O:9][C:8]([C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[N:15]([Si](C(C)C)(C(C)C)C(C)C)[CH:14]=[C:13]3[CH2:29][C@H:30]2[CH2:34][CH2:33][CH2:32][N:31]2[CH3:35])=[CH:7][CH:6]=1)=[O:4].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[CH3:1][O:2][C:3]([C:5]1[O:9][C:8]([C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[NH:15][CH:14]=[C:13]3[CH2:29][C@H:30]2[CH2:34][CH2:33][CH2:32][N:31]2[CH3:35])=[CH:7][CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 22859582HCID 22859582, compound

Product 1

HCID 22859581HCID 22859581, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-(5-Methoxycarbonyl-2-furyl)-3-(1-methylpyrrolidin-2(R)-ylmethyl)-1-triisopropylsilylindole (see Preparation 62) was reacted with tetra-n-butylammonium fluoride in tetrahydrofuran, using a procedure similar to that described in Example 62. This gave the title compound as a foam. Found: C,70.74; H,6.52; N,8.47. C20H22N2O3 requires: C,70.98; H,6.52; N,8.28%.

Sources & evidence

ORD record
ord-863e5284c4924d559bba3df797773a08
Source dataset
uspto-grants-1996_03
Patent number
US05502065

Reaction notes

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