反应详情

To (E)-2-methoxyimino-2-(2-methylphenyl)-N-methylacetamide (2.66 g, 0.01 mol), added were carbon tetrachloride (20 ml), NBS (1.96 g, 0.011 mol) and α,α'-azobis(isobutyronitrile) (0.16 g, 0.001 mol), and the reaction mixture was heated under reflux for 1 hour. After completion of the reaction, undissolved materials were removed and the remaining mixture was concentrated under reduced pressure. The residue was purified by silica gel chromatography (ethyl acetate/toluene) to give (E)-2-(2-bromomethylphenyl)-2-methoxyimino-N-methylacetamide (1.08 g; yield, 37.7%) as an oil.

1. temperaturethe reaction mixture was heated
2. temperatureunder reflux for 1 hour
3. customAfter completion of the reaction, undissolved materials
4. customwere removed
5. concentrationthe remaining mixture was concentrated under reduced pressure
6. customThe residue was purified by silica gel chromatography (ethyl acetate/toluene)