HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fmoc-Gly-OH → L-Aspartic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fmoc-Gly-OH | HCID 93124 | — |
| Reactant | Fmoc-L-tryptophan | HCID 978343 | — |
| Reactant | (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid | HCID 978356 | — |
| Reactant | Fmoc-Lys(Boc)-OH | HCID 2724628 | — |
| Reactant | Fmoc-L-Asp(OtBu)-OH | HCID 2724635 | — |
| Reactant | (2S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid | HCID 7009636 | — |
| Product | L-Aspartic Acid | HCID 5960 | — |
| Product | L-Phenylalanine | HCID 6140 | — |
| Product | L-Tryptophan | HCID 6305 | — |
| Product | N-Methylphenylalanine | HCID 6951135 | — |
Reaction Steps
Following the procedure of Table 2, Fmoc-MePhe-OH, Fmoc-Asp(OtBu)-OH, Fmoc-Ahx-OH, Fmoc-Trp-OH, Fmoc-Gly-OH, Fmoc-Lys(Boc)-OH and Hpa-OSu were sequentially coupled to the Rink amide resin. Following removal of the peptide from the resin using standard procedures the 2-methylphenylacetamide group was added to the ε-amino of Lys using o-tolylisocyanate. Amino Acid analysis following acid decomposition gave Asp 1.01 (1), Gly 1.03 (1), MePhe 0.98 (1), Lys 0.94 (1), Ahx 1.04 (1), Trp 0.96 (1). MS (FAB): m/e 1046 (M-H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05502164 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-889b22e9d42f406aa9988298f046f9c0 |
| Source note | uspto-grants-1996_03 |