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HRID1441194

反应详情

EQUATION

反应方程式

HRID 1441194 的结构方程式

REACTANTS

反应物

6
结构：O=C(O)CNC(=O)OCC1c2ccccc2-c2ccccc21
HCID93124

N-(9H-(fluoren-9-ylmethoxy)carbonyl)glycine

C17H15NO4

结构：O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)OCC1c2ccccc2-c2ccccc21
HCID978343

未命名化合物

结构：CN(C(=O)OCC1c2ccccc2-c2ccccc21)[C@@H](Cc1ccccc1)C(=O)O
HCID978356

未命名化合物

结构：CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
HCID2724628

Fmoc-Lys(Boc)-OH

C26H32N2O6

结构：CC(C)(C)OC(=O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
HCID2724635

Fmoc-L-Asp(OtBu)-OH

C23H25NO6

结构：CCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
HCID7009636

Fmoc-L-norleucine

C21H23NO4

PRODUCTS

生成物

4
结构：N[C@@H](CC(=O)O)C(=O)O
HCID5960

L-Aspartic acid

C4H7NO4

结构：N[C@@H](Cc1ccccc1)C(=O)O
HCID6140

L-Phenylalanine

C9H11NO2

结构：N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
HCID6305

L-Tryptophan

C11H12N2O2

结构：CN[C@@H](Cc1ccccc1)C(=O)O
HCID6951135

N-Methyl-L-phenylalanine

C10H13NO2

PROCEDURE

实验过程

Following the procedure of Table 2, Fmoc-MePhe-OH, Fmoc-Asp(OtBu)-OH, Fmoc-Ahx-OH, Fmoc-Trp-OH, Fmoc-Gly-OH, Fmoc-Lys(Boc)-OH and Hpa-OSu were sequentially coupled to the Rink amide resin. Following removal of the peptide from the resin using standard procedures the 2-methylphenylacetamide group was added to the ε-amino of Lys using o-tolylisocyanate. Amino Acid analysis following acid decomposition gave Asp 1.01 (1), Gly 1.03 (1), MePhe 0.98 (1), Lys 0.94 (1), Ahx 1.04 (1), Trp 0.96 (1). MS (FAB): m/e 1046 (M-H)+.

WORKUP

后处理

  1. customremoval of the peptide from the resin
  2. additionwas added to the ε-amino of Lys