反应详情

A solution of 2-(4-fluoro-phenyl)-1-phenyl-ethylamine (1.50 g) in THF was treated dropwise with 2-chloroethyl isocyanate (0.89 g) at 0° C. After stirring overnight at room temperature the solvent was evaporated and the residue dissolved in dimethoxy ethane (25 ml). DBU (1,8-diazabicyclo[5.4.0]undec-7-en) was added (1.78 g) and the reaction mixture heated under reflux for 1 hour. Column chromatography on silica yielded 1.3 g of the title compound.

1. customwas evaporated
2. dissolutionthe residue dissolved in dimethoxy ethane (25 ml)
3. additionDBU (1,8-diazabicyclo[5.4.0]undec-7-en) was added (1.78 g)
4. temperaturethe reaction mixture heated
5. temperatureunder reflux for 1 hour