HCID 68542475, compound → HCID 23088194, compound

HRID 1441221Notes

Reaction equation

HRID 1441221 reaction equation
C([O:8][C:9]1[C:14]([CH:15]([C:17]2[CH:22]=[CH:21][C:20]([CH3:23])=[C:19]([F:24])[CH:18]=2)O)=[C:13]([CH3:25])[CH:12]=[C:11]([CH3:26])[N:10]=1)C1C=CC=CC=1>C(O)C.[C].[Pd]>[F:24][C:19]1[CH:18]=[C:17]([CH:22]=[CH:21][C:20]=1[CH3:23])[CH2:15][C:14]1[C:9](=[O:8])[NH:10][C:11]([CH3:26])=[CH:12][C:13]=1[CH3:25]

Participants

4

Reactant 1

HCID 68542475HCID 68542475, compound

Product 1

HCID 23088194HCID 23088194, compoundYield 80.8%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of 2-benzyloxy-4,6-dimethylpyridin-3-yl 3-fluoro-4-methylphenyl methanol (0.39 g) in ethanol (10 mL) was added a catalytic amount of palladium carbon powder, and the mixture was stirred at room temperature under a hydrogen atmosphere overnight. After the insoluble material was removed by filtration, the solvent of the filtrate was removed to give the title compound (0.22 g).

Workup

  1. customAfter the insoluble material was removed by filtration
  2. customthe solvent of the filtrate was removed

Sources & evidence

ORD record
ord-73fb2390e4c742809d25e66043eac5a8
Source dataset
uspto-grants-2010_02
Patent number
US07655633B2

Reaction notes

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