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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1441276Generated: October 31, 2026

Ethyl 4-(methylamino)-2-(methylsulfanyl)pyrimidine-5-carboxylate → (4-(Methylamino)-2-(methylthio)pyrimidin-5-yl)methanol

https://huagongshe.com/reaction/1441276

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 4-(methylamino)-2-(methylsulfanyl)pyrimidine-5-carboxylateHCID 295697—
ReactantAluminium lithium hydrideHCID 21226445—
SolventTetrahydrofuranHCID 8028—
Product(4-(Methylamino)-2-(methylthio)pyrimidin-5-yl)methanolHCID 10679092—

Reaction Steps

(4-Methylamino-2-methylsulfanyl-pyrimidin-5-yl)-methanol was prepared by reduction of 4-methylamino-2-methylsulfanylpyrimidine-5-carboxylic acid ethyl ester with lithium aluminiumhydride in tetrahydrofuran (THF) at temperatures ranging from 5° C. to room temperature (RT).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07655651B2
Source datasetuspto-grants-2010_02
ORD IDord-ce40d753ac6c473ebdbbbe8c7983e08b
Source noteuspto-grants-2010_02