Ethyl 4-(methylamino)-2-(methylsulfanyl)pyrimidine-5-carboxylate → (4-(Methylamino)-2-(methylthio)pyrimidin-5-yl)methanol

HRID 1441276Notes

Reaction equation

HRID 1441276 reaction equation
C([O:3][C:4]([C:6]1[C:7]([NH:14][CH3:15])=[N:8][C:9]([S:12][CH3:13])=[N:10][CH:11]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:15][NH:14][C:7]1[C:6]([CH2:4][OH:3])=[CH:11][N:10]=[C:9]([S:12][CH3:13])[N:8]=1

Participants

4

Reactant 2

HCID 295697Ethyl 4-(methylamino)-2-(methylsulfanyl)pyrimidine-5-carboxylateHCID 21226445Aluminium lithium hydride

Product 1

HCID 10679092(4-(Methylamino)-2-(methylthio)pyrimidin-5-yl)methanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(4-Methylamino-2-methylsulfanyl-pyrimidin-5-yl)-methanol was prepared by reduction of 4-methylamino-2-methylsulfanylpyrimidine-5-carboxylic acid ethyl ester with lithium aluminiumhydride in tetrahydrofuran (THF) at temperatures ranging from 5° C. to room temperature (RT).

Workup

  1. customranging from 5° C. to room temperature
  2. custom(RT)

Sources & evidence

ORD record
ord-ce40d753ac6c473ebdbbbe8c7983e08b
Source dataset
uspto-grants-2010_02
Patent number
US07655651B2

Reaction notes

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