HCID 67037166, compound → HCID 68688173, compound

HRID 1441322Notes

Reaction equation

HRID 1441322 reaction equation
[CH:1]1([N:5]2[C:9]([C:10](=O)/[C:11](/[F:16])=[CH:12]/N(C)C)=[CH:8][N:7]=[C:6]2[CH3:18])[CH2:4][CH2:3][CH2:2]1.[N:19]1([C:25]2[CH:30]=[CH:29][C:28]([NH:31][C:32]([NH2:34])=[NH:33])=[CH:27][CH:26]=2)[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[O:22]1[CH2:23][CH2:24][N:19]([C:25]2[CH:26]=[CH:27][C:28]([NH:31][C:32]3[N:34]=[C:10]([C:9]4[N:5]([CH:1]5[CH2:4][CH2:3][CH2:2]5)[C:6]([CH3:18])=[N:7][CH:8]=4)[C:11]([F:16])=[CH:12][N:33]=3)=[CH:29][CH:30]=2)[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 67037166HCID 67037166, compoundHCID 178512567HCID 178512567, compound

Product 1

HCID 68688173HCID 68688173, compound

Procedure

The title compound was prepared from (2Z)-1-(1-cyclobutyl-2-methyl-1H-imidazol-5-yl)-3-(dimethylamino)-2-fluoroprop-2-en-1-one (Method 16; 234 mg) and N-(4-morpholin-4-ylphenyl)guanidine (Method 4; 410 mg) by the procedure of Example 111 to yield a white solid (288 mg, 76%). NMR: 1.61-1.72 (m, 2H), 2.29-2.45 (m, 4H), 2.75 (s, 3H), 3.26-3.34 (m, 4H), 3.90-3.97 (m, 4H), 5.22 (quintet, 1H), 7.38-7.45 (m, 2H), 7.68 (d, 2H), 8.08 (d, 1H), 8.73 (d, 1H), 9.95 (brs, 1H); m/z 409.

Sources & evidence

ORD record
ord-94f3c0c6a04e4efbb3155b81589e08bb
Source dataset
uspto-grants-2010_02
Patent number
US07655652B2

Reaction notes

Loading…