HCID 68689654, compound → HCID 69385700, compound

HRID 1441345Notes

Reaction equation

HRID 1441345 reaction equation
[C:1]([N:5]([C:9]1[CH:10]=[N:11][O:12][C:13]=1[CH3:14])[CH:6]([CH3:8])[CH3:7])(=[O:4])[CH2:2][CH3:3]>[Pd].CCO>[C:13](/[C:9](/[N:5]([CH:6]([CH3:7])[CH3:8])[C:1](=[O:4])[CH2:2][CH3:3])=[CH:10]\[NH2:11])(=[O:12])[CH3:14]

Participants

4

Reactant 1

HCID 68689654HCID 68689654, compound

Product 1

HCID 69385700HCID 69385700, compoundYield 105.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-[N-(Propionyl)-N-(isopropyl)amino]-5-methylisoxazole (Method 6; 330 g, 1.0 eq.) was stirred under hydrogen (1.0 eq), with 10% palladium on carbon (0.1 eq.) in EtOH (10 vol.eq.) at 25° C. overnight. The catalyst was removed by filtration and the EtOH was removed in vacuo to leave an off white solid (351 g, 98%). This was used without further purification.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe EtOH was removed in vacuo

Sources & evidence

ORD record
ord-c79c5cfb24eb4020bac32dd704953c85
Source dataset
uspto-grants-2010_02
Patent number
US07655652B2

Reaction notes

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