HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → (3r)-1-(4-Nitrophenyl)pyrrolidin-3-amine trifluoroacetate salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl [(3R)-1-(4-nitrophenyl)pyrrolidin-3-yl]carbamate | HCID 86594863 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (3r)-1-(4-Nitrophenyl)pyrrolidin-3-amine trifluoroacetate salt | HCID 68688649 | 93% |
Reaction Steps
tert-Butyl[(3R)-1-(4-nitrophenyl)pyrrolidin-3-yl]carbamate (Method 40; 1.0 g, 3.26 mmol) in DCM (15 ml) was reacted with TFA (7.5 ml) at room temperature for 18 hours. Pouring into cold ether (200 ml) gave on filtration the title compound (0.97 g, 93%). NMR: 2.03-2.17 (m, 1H), 2.22-2.44 (m, 1H), 3.40-3.60 (m, 3H), 3.68-3.74 (m, 1H), 3.95-4.08 (m, 1H), 6.66 (d, 2H), 8.08 (d, 2H), 8.14 (s, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07655652B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-3b2b9258dc5a4965a52d09fcbca602e2 |
| Source note | uspto-grants-2010_02 |