huagongshe.com
HRID1441365

反应详情

EQUATION

反应方程式

HRID 1441365 的结构方程式

REACTANTS

反应物

3
结构：CCOCC
HCID3283

Diethyl Ether

C4H10O

结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)N[C@@H]1CCN(c2ccc([N+](=O)[O-])cc2)C1
HCID86594863

未命名化合物

PRODUCTS

生成物

1
结构：N[C@@H]1CCN(c2ccc([N+](=O)[O-])cc2)C1.O=C(O)C(F)(F)F
HCID68688649

未命名化合物

收率 93%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

tert-Butyl[(3R)-1-(4-nitrophenyl)pyrrolidin-3-yl]carbamate (Method 40; 1.0 g, 3.26 mmol) in DCM (15 ml) was reacted with TFA (7.5 ml) at room temperature for 18 hours. Pouring into cold ether (200 ml) gave on filtration the title compound (0.97 g, 93%). NMR: 2.03-2.17 (m, 1H), 2.22-2.44 (m, 1H), 3.40-3.60 (m, 3H), 3.68-3.74 (m, 1H), 3.95-4.08 (m, 1H), 6.66 (d, 2H), 8.08 (d, 2H), 8.14 (s, 2H).