反应详情

4-Fluoronitrobenzene (0.47 g, 3.34 mmol), potassium carbonate (1.39, 10 mmol) and (R)-pyrrolidine-2-carboxylic acid dimethylamide (0.50, 3.52 mmol) were pre-mixed in acetonitrile (40 ml) and heated at reflux for 36 hours. The reaction was quenched with saturated ammonium chloride (40 ml), extracted with DCM (2×100 ml), dried and solvent removed in vacuo to yield the title compound as a yellow solid. Ether was added and the solid was stirred, filtered and dried (0.85 g, 96%). M/z 264.

1. temperatureheated
2. temperatureat reflux for 36 hours
3. customThe reaction was quenched with saturated ammonium chloride (40 ml)
4. extractionextracted with DCM (2×100 ml)
5. customdried
6. customsolvent removed in vacuo