Potassium Hydroxide → HCID 59023296, compound

HRID 1441389Notes

Reaction equation

HRID 1441389 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[C:13]3=[C:14]([N+:19]([O-:21])=[O:20])[CH2:15][CH2:16][C:17](=O)[N:12]3[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.Cl.[NH2:23][OH:24].[OH-].[K+]>C(O)C>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[C:13]3=[C:14]([N+:19]([O-:21])=[O:20])[CH2:15][CH2:16]/[C:17](=[N:23]\[OH:24])/[N:12]3[CH2:11][CH2:10]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 14675675HCID 14675675, compound

Product 1

HCID 59023296HCID 59023296, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 0.618 g (0.002 mol) of 1-((6-chloropyridin-3-yl)methyl)-8-nitro-2,3,6,7-tetrahydroimidazo[1,2-a]pyridin-5(1H)-one, 0.01 mol of hydroxylamine hydrochloride, 0.01 mol of potassium hydroxide and 20 ml of ethanol placed in a 100 ml of flask was refluxed for 24 hours. The solvent was removed and the residue was separated to give a product by column chromatography in 65% yield.

Workup

  1. customplaced in a 100 ml of flask
  2. temperaturewas refluxed for 24 hours
  3. customThe solvent was removed
  4. customthe residue was separated
  5. customto give a product by column chromatography in 65% yield

Sources & evidence

ORD record
ord-82b2dbdaa89f47b386cd135bea27773d
Source dataset
uspto-grants-2010_02
Patent number
US07655665B2

Reaction notes

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